diff --git a/esphome/components/openthread/openthread.cpp b/esphome/components/openthread/openthread.cpp
index acf6f42973..ccafb50e56 100644
--- a/esphome/components/openthread/openthread.cpp
+++ b/esphome/components/openthread/openthread.cpp
@@ -1,5 +1,4 @@
 #include "esphome/core/defines.h"
-#define USE_OPENTHREAD
 #ifdef USE_OPENTHREAD
 #include "openthread.h"