diff --git a/esphome/components/i2c/i2c.cpp b/esphome/components/i2c/i2c.cpp
index fdc9fd1ddf..2b2190d28b 100644
--- a/esphome/components/i2c/i2c.cpp
+++ b/esphome/components/i2c/i2c.cpp
@@ -14,6 +14,14 @@ ErrorCode I2CDevice::read_register(uint8_t a_register, uint8_t *data, size_t len
   return bus_->read(address_, data, len);
 }
 
+ErrorCode I2CDevice::read_register16(uint16_t a_register, uint8_t *data, size_t len, bool stop) {
+  a_register = convert_big_endian(a_register);
+  ErrorCode const err = this->write(reinterpret_cast<const uint8_t *>(&a_register), 2, stop);
+  if (err != ERROR_OK)
+    return err;
+  return bus_->read(address_, data, len);
+}
+
 ErrorCode I2CDevice::write_register(uint8_t a_register, const uint8_t *data, size_t len, bool stop) {
   WriteBuffer buffers[2];
   buffers[0].data = &a_register;
@@ -23,6 +31,16 @@ ErrorCode I2CDevice::write_register(uint8_t a_register, const uint8_t *data, siz
   return bus_->writev(address_, buffers, 2, stop);
 }
 
+ErrorCode I2CDevice::write_register16(uint16_t a_register, const uint8_t *data, size_t len, bool stop) {
+  a_register = convert_big_endian(a_register);
+  WriteBuffer buffers[2];
+  buffers[0].data = reinterpret_cast<const uint8_t *>(&a_register);
+  buffers[0].len = 2;
+  buffers[1].data = data;
+  buffers[1].len = len;
+  return bus_->writev(address_, buffers, 2, stop);
+}
+
 bool I2CDevice::read_bytes_16(uint8_t a_register, uint16_t *data, uint8_t len) {
   if (read_register(a_register, reinterpret_cast<uint8_t *>(data), len * 2) != ERROR_OK)
     return false;
@@ -60,5 +78,26 @@ uint8_t I2CRegister::get() const {
   return value;
 }
 
+I2CRegister16 &I2CRegister16::operator=(uint8_t value) {
+  this->parent_->write_register16(this->register_, &value, 1);
+  return *this;
+}
+I2CRegister16 &I2CRegister16::operator&=(uint8_t value) {
+  value &= get();
+  this->parent_->write_register16(this->register_, &value, 1);
+  return *this;
+}
+I2CRegister16 &I2CRegister16::operator|=(uint8_t value) {
+  value |= get();
+  this->parent_->write_register16(this->register_, &value, 1);
+  return *this;
+}
+
+uint8_t I2CRegister16::get() const {
+  uint8_t value = 0x00;
+  this->parent_->read_register16(this->register_, &value, 1);
+  return value;
+}
+
 }  // namespace i2c
 }  // namespace esphome
diff --git a/esphome/components/i2c/i2c.h b/esphome/components/i2c/i2c.h
index 780528a5c7..eb5d463b65 100644
--- a/esphome/components/i2c/i2c.h
+++ b/esphome/components/i2c/i2c.h
@@ -31,6 +31,25 @@ class I2CRegister {
   uint8_t register_;
 };
 
+class I2CRegister16 {
+ public:
+  I2CRegister16 &operator=(uint8_t value);
+  I2CRegister16 &operator&=(uint8_t value);
+  I2CRegister16 &operator|=(uint8_t value);
+
+  explicit operator uint8_t() const { return get(); }
+
+  uint8_t get() const;
+
+ protected:
+  friend class I2CDevice;
+
+  I2CRegister16(I2CDevice *parent, uint16_t a_register) : parent_(parent), register_(a_register) {}
+
+  I2CDevice *parent_;
+  uint16_t register_;
+};
+
 // like ntohs/htons but without including networking headers.
 // ("i2c" byte order is big-endian)
 inline uint16_t i2ctohs(uint16_t i2cshort) { return convert_big_endian(i2cshort); }
@@ -44,12 +63,15 @@ class I2CDevice {
   void set_i2c_bus(I2CBus *bus) { bus_ = bus; }
 
   I2CRegister reg(uint8_t a_register) { return {this, a_register}; }
+  I2CRegister16 reg16(uint16_t a_register) { return {this, a_register}; }
 
   ErrorCode read(uint8_t *data, size_t len) { return bus_->read(address_, data, len); }
   ErrorCode read_register(uint8_t a_register, uint8_t *data, size_t len, bool stop = true);
+  ErrorCode read_register16(uint16_t a_register, uint8_t *data, size_t len, bool stop = true);
 
   ErrorCode write(const uint8_t *data, uint8_t len, bool stop = true) { return bus_->write(address_, data, len, stop); }
   ErrorCode write_register(uint8_t a_register, const uint8_t *data, size_t len, bool stop = true);
+  ErrorCode write_register16(uint16_t a_register, const uint8_t *data, size_t len, bool stop = true);
 
   // Compat APIs