diff --git a/esphome/components/deep_sleep/deep_sleep_component.cpp b/esphome/components/deep_sleep/deep_sleep_component.cpp
index 328e972e6b..97fdf11366 100644
--- a/esphome/components/deep_sleep/deep_sleep_component.cpp
+++ b/esphome/components/deep_sleep/deep_sleep_component.cpp
@@ -81,7 +81,7 @@ void DeepSleepComponent::set_wakeup_pin_mode(WakeupPinMode wakeup_pin_mode) {
 #endif
 
 #if defined(USE_ESP32)
-#if !defined(USE_ESP32_VARIANT_ESP32C3)
+#if !defined(USE_ESP32_VARIANT_ESP32C3) && !defined(USE_ESP32_VARIANT_ESP32C6)
 
 void DeepSleepComponent::set_ext1_wakeup(Ext1Wakeup ext1_wakeup) { this->ext1_wakeup_ = ext1_wakeup; }
 
@@ -121,7 +121,7 @@ void DeepSleepComponent::begin_sleep(bool manual) {
   App.run_safe_shutdown_hooks();
 
 #if defined(USE_ESP32)
-#if !defined(USE_ESP32_VARIANT_ESP32C3)
+#if !defined(USE_ESP32_VARIANT_ESP32C3) && !defined(USE_ESP32_VARIANT_ESP32C6)
   if (this->sleep_duration_.has_value())
     esp_sleep_enable_timer_wakeup(*this->sleep_duration_);
   if (this->wakeup_pin_ != nullptr) {
@@ -140,7 +140,7 @@ void DeepSleepComponent::begin_sleep(bool manual) {
     esp_sleep_pd_config(ESP_PD_DOMAIN_RTC_PERIPH, ESP_PD_OPTION_ON);
   }
 #endif
-#ifdef USE_ESP32_VARIANT_ESP32C3
+#if defined(USE_ESP32_VARIANT_ESP32C3) || defined(USE_ESP32_VARIANT_ESP32C6)
   if (this->sleep_duration_.has_value())
     esp_sleep_enable_timer_wakeup(*this->sleep_duration_);
   if (this->wakeup_pin_ != nullptr) {