diff --git a/esphome/components/mcp3221/__init__.py b/esphome/components/mcp3221/__init__.py
new file mode 100644
index 0000000000..677bb78c35
--- /dev/null
+++ b/esphome/components/mcp3221/__init__.py
@@ -0,0 +1 @@
+CODEOWNERS = ["@philippderdiedas"]
diff --git a/esphome/components/mcp3221/mcp3221_sensor.cpp b/esphome/components/mcp3221/mcp3221_sensor.cpp
new file mode 100644
index 0000000000..2164bc32ad
--- /dev/null
+++ b/esphome/components/mcp3221/mcp3221_sensor.cpp
@@ -0,0 +1,41 @@
+#include "mcp3221_sensor.h"
+#include "esphome/core/hal.h"
+#include "esphome/core/log.h"
+
+namespace esphome {
+namespace mcp3221 {
+
+static const char *const TAG = "mcp3221";
+
+void MCP3221Sensor::setup() {
+  ESP_LOGCONFIG(TAG, "Probing MCP3221...");
+
+  if (!this->write(nullptr, 0)) {
+    this->mark_failed();
+    return;
+  }
+}
+
+float MCP3221Sensor::get_setup_priority() const { return setup_priority::DATA; }
+
+float MCP3221Sensor::sample() {
+  uint8_t data[2];
+  if (!this->read(data, 2)) {
+    ESP_LOGW(TAG, "Failed to read data from MCP3221");
+    this->status_set_warning();
+    return NAN;
+  }
+
+  uint16_t value = (data[0] << 8) | data[1];
+  float voltage = value * this->reference_voltage_ / 4096.0f;
+
+  return voltage;
+}
+
+void MCP3221Sensor::update() {
+  float v = this->sample();
+  this->publish_state(v);
+}
+
+}  // namespace mcp3221
+}  // namespace esphome
diff --git a/esphome/components/mcp3221/mcp3221_sensor.h b/esphome/components/mcp3221/mcp3221_sensor.h
new file mode 100644
index 0000000000..5d54638a30
--- /dev/null
+++ b/esphome/components/mcp3221/mcp3221_sensor.h
@@ -0,0 +1,30 @@
+#pragma once
+
+#include "esphome/core/component.h"
+#include "esphome/core/automation.h"
+#include "esphome/components/sensor/sensor.h"
+#include "esphome/components/i2c/i2c.h"
+#include "esphome/components/voltage_sampler/voltage_sampler.h"
+
+#include <cinttypes>
+
+namespace esphome {
+namespace mcp3221 {
+
+class MCP3221Sensor : public sensor::Sensor,
+                      public PollingComponent,
+                      public voltage_sampler::VoltageSampler,
+                      public i2c::I2CDevice {
+ public:
+  void setup() override;
+  void set_reference_voltage(float reference_voltage) { this->reference_voltage_ = reference_voltage; }
+  float get_setup_priority() const override;
+  void update() override;
+  float sample() override;
+
+ protected:
+  float reference_voltage_;
+};
+
+}  // namespace mcp3221
+}  // namespace esphome
diff --git a/esphome/components/mcp3221/sensor.py b/esphome/components/mcp3221/sensor.py
new file mode 100644
index 0000000000..df04d1e72e
--- /dev/null
+++ b/esphome/components/mcp3221/sensor.py
@@ -0,0 +1,47 @@
+import esphome.codegen as cg
+from esphome.components import i2c, sensor
+import esphome.config_validation as cv
+from esphome.const import (
+    CONF_RAW,
+    CONF_REFERENCE_VOLTAGE,
+    DEVICE_CLASS_VOLTAGE,
+    ICON_SCALE,
+    STATE_CLASS_MEASUREMENT,
+    UNIT_VOLT,
+)
+
+DEPENDENCIES = ["i2c"]
+
+# CONF_CONTINUOUS_MODE = "continuous_mode"
+
+
+mcp3221_ns = cg.esphome_ns.namespace("mcp3221")
+MCP3221Sensor = mcp3221_ns.class_(
+    "MCP3221Sensor", sensor.Sensor, cg.PollingComponent, i2c.I2CDevice
+)
+
+
+CONFIG_SCHEMA = (
+    sensor.sensor_schema(
+        MCP3221Sensor,
+        icon=ICON_SCALE,
+        accuracy_decimals=0,
+        state_class=STATE_CLASS_MEASUREMENT,
+        device_class=DEVICE_CLASS_VOLTAGE,
+        unit_of_measurement=UNIT_VOLT,
+    )
+    .extend(
+        {
+            cv.Optional(CONF_REFERENCE_VOLTAGE, default="3.3V"): cv.voltage,
+            cv.Optional(CONF_RAW, default=False): cv.boolean,
+        }
+    )
+    .extend(cv.polling_component_schema("60s"))
+    .extend(i2c.i2c_device_schema(0x48))
+)
+
+
+async def to_code(config):
+    var = await sensor.new_sensor(config)
+    await cg.register_component(var, config)
+    await i2c.register_i2c_device(var, config)