diff --git a/esphome/core/defines.h b/esphome/core/defines.h
index 672ca1e6ea..bc961487cc 100644
--- a/esphome/core/defines.h
+++ b/esphome/core/defines.h
@@ -47,7 +47,6 @@
 #define USE_LVGL_KEYBOARD
 #define USE_LVGL_ROTARY_ENCODER
 #define USE_LVGL_TOUCHSCREEN
-#define USE_MD5
 #define USE_MDNS
 #define USE_MEDIA_PLAYER
 #define USE_NEXTION_TFT_UPLOAD