diff --git a/esphome/components/wireguard/__init__.py b/esphome/components/wireguard/__init__.py
index 16d0d0226e..5e34a8a19b 100644
--- a/esphome/components/wireguard/__init__.py
+++ b/esphome/components/wireguard/__init__.py
@@ -1,19 +1,20 @@
-import re
 import ipaddress
+import re
+
+from esphome import automation
 import esphome.codegen as cg
+from esphome.components import time
+from esphome.components.esp32 import CORE, add_idf_sdkconfig_option
 import esphome.config_validation as cv
 from esphome.const import (
-    CONF_ID,
-    CONF_TIME_ID,
     CONF_ADDRESS,
+    CONF_ID,
     CONF_REBOOT_TIMEOUT,
+    CONF_TIME_ID,
     KEY_CORE,
     KEY_FRAMEWORK_VERSION,
 )
-from esphome.components.esp32 import CORE, add_idf_sdkconfig_option
-from esphome.components import time
 from esphome.core import TimePeriod
-from esphome import automation
 
 CONF_NETMASK = "netmask"
 CONF_PRIVATE_KEY = "private_key"
@@ -91,6 +92,8 @@ CONFIG_SCHEMA = cv.Schema(
 async def to_code(config):
     var = cg.new_Pvariable(config[CONF_ID])
 
+    cg.add_define("USE_WIREGUARD")
+
     cg.add(var.set_address(str(config[CONF_ADDRESS])))
     cg.add(var.set_netmask(str(config[CONF_NETMASK])))
     cg.add(var.set_private_key(config[CONF_PRIVATE_KEY]))
diff --git a/esphome/components/wireguard/wireguard.cpp b/esphome/components/wireguard/wireguard.cpp
index 17ebc701e3..7b4011cb79 100644
--- a/esphome/components/wireguard/wireguard.cpp
+++ b/esphome/components/wireguard/wireguard.cpp
@@ -1,5 +1,5 @@
 #include "wireguard.h"
-
+#ifdef USE_WIREGUARD
 #include <cinttypes>
 #include <ctime>
 #include <functional>
@@ -289,3 +289,4 @@ std::string mask_key(const std::string &key) { return (key.substr(0, 5) + "[...]
 
 }  // namespace wireguard
 }  // namespace esphome
+#endif
diff --git a/esphome/components/wireguard/wireguard.h b/esphome/components/wireguard/wireguard.h
index a0e9e27a1b..5db9a48c90 100644
--- a/esphome/components/wireguard/wireguard.h
+++ b/esphome/components/wireguard/wireguard.h
@@ -1,5 +1,6 @@
 #pragma once
-
+#include "esphome/core/defines.h"
+#ifdef USE_WIREGUARD
 #include <ctime>
 #include <vector>
 #include <tuple>
@@ -170,3 +171,4 @@ template<typename... Ts> class WireguardDisableAction : public Action<Ts...>, pu
 
 }  // namespace wireguard
 }  // namespace esphome
+#endif
diff --git a/esphome/core/defines.h b/esphome/core/defines.h
index a4d473b76e..52cf7d4dd0 100644
--- a/esphome/core/defines.h
+++ b/esphome/core/defines.h
@@ -75,6 +75,7 @@
 #define USE_VALVE
 #define USE_WIFI
 #define USE_WIFI_AP
+#define USE_WIREGUARD
 
 // Arduino-specific feature flags
 #ifdef USE_ARDUINO