diff --git a/CODEOWNERS b/CODEOWNERS
index 0a1f2b3ed2..a726f85cf1 100644
--- a/CODEOWNERS
+++ b/CODEOWNERS
@@ -95,6 +95,7 @@ esphome/components/st7789v/* @kbx81
 esphome/components/substitutions/* @esphome/core
 esphome/components/sun/* @OttoWinter
 esphome/components/switch/* @esphome/core
+esphome/components/tca9548a/* @andreashergert1984
 esphome/components/tcl112/* @glmnet
 esphome/components/teleinfo/* @0hax
 esphome/components/thermostat/* @kbx81
diff --git a/esphome/components/i2c/__init__.py b/esphome/components/i2c/__init__.py
index 1446835904..59f90842e1 100644
--- a/esphome/components/i2c/__init__.py
+++ b/esphome/components/i2c/__init__.py
@@ -2,6 +2,7 @@ import esphome.codegen as cg
 import esphome.config_validation as cv
 from esphome import pins
 from esphome.const import (
+    CONF_CHANNEL,
     CONF_FREQUENCY,
     CONF_ID,
     CONF_SCAN,
@@ -9,6 +10,7 @@ from esphome.const import (
     CONF_SDA,
     CONF_ADDRESS,
     CONF_I2C_ID,
+    CONF_MULTIPLEXER,
 )
 from esphome.core import coroutine, coroutine_with_priority
 
@@ -16,6 +18,7 @@ CODEOWNERS = ["@esphome/core"]
 i2c_ns = cg.esphome_ns.namespace("i2c")
 I2CComponent = i2c_ns.class_("I2CComponent", cg.Component)
 I2CDevice = i2c_ns.class_("I2CDevice")
+I2CMultiplexer = i2c_ns.class_("I2CMultiplexer", I2CDevice)
 
 MULTI_CONF = True
 CONFIG_SCHEMA = cv.Schema(
@@ -30,6 +33,13 @@ CONFIG_SCHEMA = cv.Schema(
     }
 ).extend(cv.COMPONENT_SCHEMA)
 
+I2CMULTIPLEXER_SCHEMA = cv.Schema(
+    {
+        cv.Required(CONF_ID): cv.use_id(I2CMultiplexer),
+        cv.Required(CONF_CHANNEL): cv.uint8_t,
+    }
+)
+
 
 @coroutine_with_priority(1.0)
 def to_code(config):
@@ -53,6 +63,7 @@ def i2c_device_schema(default_address):
     """
     schema = {
         cv.GenerateID(CONF_I2C_ID): cv.use_id(I2CComponent),
+        cv.Optional(CONF_MULTIPLEXER): I2CMULTIPLEXER_SCHEMA,
     }
     if default_address is None:
         schema[cv.Required(CONF_ADDRESS)] = cv.i2c_address
@@ -72,3 +83,8 @@ def register_i2c_device(var, config):
     parent = yield cg.get_variable(config[CONF_I2C_ID])
     cg.add(var.set_i2c_parent(parent))
     cg.add(var.set_i2c_address(config[CONF_ADDRESS]))
+    if CONF_MULTIPLEXER in config:
+        multiplexer = yield cg.get_variable(config[CONF_MULTIPLEXER][CONF_ID])
+        cg.add(
+            var.set_i2c_multiplexer(multiplexer, config[CONF_MULTIPLEXER][CONF_CHANNEL])
+        )
diff --git a/esphome/components/i2c/i2c.cpp b/esphome/components/i2c/i2c.cpp
index 8e6d9f32fa..e9a7e72932 100644
--- a/esphome/components/i2c/i2c.cpp
+++ b/esphome/components/i2c/i2c.cpp
@@ -178,28 +178,67 @@ bool I2CComponent::write_byte_16(uint8_t address, uint8_t a_register, uint16_t d
 }
 
 void I2CDevice::set_i2c_address(uint8_t address) { this->address_ = address; }
+#ifdef USE_I2C_MULTIPLEXER
+void I2CDevice::set_i2c_multiplexer(I2CMultiplexer *multiplexer, uint8_t channel) {
+  ESP_LOGVV(TAG, "    Setting Multiplexer %p for channel %d", multiplexer, channel);
+  this->multiplexer_ = multiplexer;
+  this->channel_ = channel;
+}
+
+void I2CDevice::check_multiplexer_() {
+  if (this->multiplexer_ != nullptr) {
+    ESP_LOGVV(TAG, "Multiplexer setting channel to %d", this->channel_);
+    this->multiplexer_->set_channel(this->channel_);
+  }
+}
+#endif
+
 bool I2CDevice::read_bytes(uint8_t a_register, uint8_t *data, uint8_t len, uint32_t conversion) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->read_bytes(this->address_, a_register, data, len, conversion);
 }
 bool I2CDevice::read_byte(uint8_t a_register, uint8_t *data, uint32_t conversion) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->read_byte(this->address_, a_register, data, conversion);
 }
 bool I2CDevice::write_bytes(uint8_t a_register, const uint8_t *data, uint8_t len) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->write_bytes(this->address_, a_register, data, len);
 }
 bool I2CDevice::write_byte(uint8_t a_register, uint8_t data) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->write_byte(this->address_, a_register, data);
 }
 bool I2CDevice::read_bytes_16(uint8_t a_register, uint16_t *data, uint8_t len, uint32_t conversion) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->read_bytes_16(this->address_, a_register, data, len, conversion);
 }
 bool I2CDevice::read_byte_16(uint8_t a_register, uint16_t *data, uint32_t conversion) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->read_byte_16(this->address_, a_register, data, conversion);
 }
 bool I2CDevice::write_bytes_16(uint8_t a_register, const uint16_t *data, uint8_t len) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->write_bytes_16(this->address_, a_register, data, len);
 }
 bool I2CDevice::write_byte_16(uint8_t a_register, uint16_t data) {  // NOLINT
+#ifdef USE_I2C_MULTIPLEXER
+  this->check_multiplexer_();
+#endif
   return this->parent_->write_byte_16(this->address_, a_register, data);
 }
 void I2CDevice::set_i2c_parent(I2CComponent *parent) { this->parent_ = parent; }
diff --git a/esphome/components/i2c/i2c.h b/esphome/components/i2c/i2c.h
index 72777f8eb0..56da64c218 100644
--- a/esphome/components/i2c/i2c.h
+++ b/esphome/components/i2c/i2c.h
@@ -1,6 +1,7 @@
 #pragma once
 
 #include <Wire.h>
+#include "esphome/core/defines.h"
 #include "esphome/core/component.h"
 #include "esphome/core/helpers.h"
 
@@ -135,7 +136,7 @@ extern uint8_t next_i2c_bus_num_;
 #endif
 
 class I2CDevice;
-
+class I2CMultiplexer;
 class I2CRegister {
  public:
   I2CRegister(I2CDevice *parent, uint8_t a_register) : parent_(parent), register_(a_register) {}
@@ -167,7 +168,10 @@ class I2CDevice {
 
   /// Manually set the i2c address of this device.
   void set_i2c_address(uint8_t address);
-
+#ifdef USE_I2C_MULTIPLEXER
+  /// Manually set the i2c multiplexer of this device.
+  void set_i2c_multiplexer(I2CMultiplexer *multiplexer, uint8_t channel);
+#endif
   /// Manually set the parent i2c bus for this device.
   void set_i2c_parent(I2CComponent *parent);
 
@@ -280,9 +284,19 @@ class I2CDevice {
   bool write_byte_16(uint8_t a_register, uint16_t data);
 
  protected:
+  // Checks for multiplexer set and set channel
+  void check_multiplexer_();
   uint8_t address_{0x00};
   I2CComponent *parent_{nullptr};
+#ifdef USE_I2C_MULTIPLEXER
+  I2CMultiplexer *multiplexer_{nullptr};
+  uint8_t channel_;
+#endif
+};
+class I2CMultiplexer : public I2CDevice {
+ public:
+  I2CMultiplexer() = default;
+  virtual void set_channel(uint8_t channelno);
 };
-
 }  // namespace i2c
 }  // namespace esphome
diff --git a/esphome/components/tca9548a/__init__.py b/esphome/components/tca9548a/__init__.py
new file mode 100644
index 0000000000..aedd751086
--- /dev/null
+++ b/esphome/components/tca9548a/__init__.py
@@ -0,0 +1,30 @@
+import esphome.codegen as cg
+import esphome.config_validation as cv
+from esphome.components import i2c
+from esphome.const import CONF_ID, CONF_SCAN
+
+CODEOWNERS = ["@andreashergert1984"]
+
+DEPENDENCIES = ["i2c"]
+
+tca9548a_ns = cg.esphome_ns.namespace("tca9548a")
+TCA9548AComponent = tca9548a_ns.class_(
+    "TCA9548AComponent", cg.PollingComponent, i2c.I2CMultiplexer
+)
+
+MULTI_CONF = True
+
+CONFIG_SCHEMA = cv.Schema(
+    {
+        cv.GenerateID(): cv.declare_id(TCA9548AComponent),
+        cv.Optional(CONF_SCAN, default=True): cv.boolean,
+    }
+).extend(i2c.i2c_device_schema(0x70))
+
+
+def to_code(config):
+    var = cg.new_Pvariable(config[CONF_ID])
+    cg.add_define("USE_I2C_MULTIPLEXER")
+    yield cg.register_component(var, config)
+    yield i2c.register_i2c_device(var, config)
+    cg.add(var.set_scan(config[CONF_SCAN]))
diff --git a/esphome/components/tca9548a/tca9548a.cpp b/esphome/components/tca9548a/tca9548a.cpp
new file mode 100644
index 0000000000..0df60d6dd2
--- /dev/null
+++ b/esphome/components/tca9548a/tca9548a.cpp
@@ -0,0 +1,41 @@
+#include "tca9548a.h"
+#include "esphome/core/log.h"
+
+namespace esphome {
+namespace tca9548a {
+
+static const char *TAG = "tca9548a";
+
+void TCA9548AComponent::setup() {
+  ESP_LOGCONFIG(TAG, "Setting up TCA9548A...");
+  uint8_t status = 0;
+  if (!this->read_byte(0x00, &status)) {
+    ESP_LOGI(TAG, "TCA9548A failed");
+    return;
+  }
+  // out of range to make sure on first set_channel a new one will be set
+  this->current_channelno_ = 8;
+  ESP_LOGCONFIG(TAG, "Channels currently open: %d", status);
+}
+void TCA9548AComponent::dump_config() {
+  ESP_LOGCONFIG(TAG, "TCA9548A:");
+  LOG_I2C_DEVICE(this);
+  if (this->scan_) {
+    for (uint8_t i = 0; i < 8; i++) {
+      ESP_LOGCONFIG(TAG, "Activating channel: %d", i);
+      this->set_channel(i);
+      this->parent_->dump_config();
+    }
+  }
+}
+
+void TCA9548AComponent::set_channel(uint8_t channelno) {
+  if (this->current_channelno_ != channelno) {
+    this->current_channelno_ = channelno;
+    uint8_t channelbyte = 1 << channelno;
+    this->write_byte(0x70, channelbyte);
+  }
+}
+
+}  // namespace tca9548a
+}  // namespace esphome
diff --git a/esphome/components/tca9548a/tca9548a.h b/esphome/components/tca9548a/tca9548a.h
new file mode 100644
index 0000000000..50b1eb8b56
--- /dev/null
+++ b/esphome/components/tca9548a/tca9548a.h
@@ -0,0 +1,22 @@
+#pragma once
+
+#include "esphome/core/component.h"
+#include "esphome/components/i2c/i2c.h"
+
+namespace esphome {
+namespace tca9548a {
+
+class TCA9548AComponent : public Component, public i2c::I2CMultiplexer {
+ public:
+  void set_scan(bool scan) { scan_ = scan; }
+  void setup() override;
+  void dump_config() override;
+  void update();
+  void set_channel(uint8_t channelno) override;
+
+ protected:
+  bool scan_;
+  uint8_t current_channelno_;
+};
+}  // namespace tca9548a
+}  // namespace esphome
diff --git a/tests/test1.yaml b/tests/test1.yaml
index bcd4460d3c..e9b4cdf67c 100644
--- a/tests/test1.yaml
+++ b/tests/test1.yaml
@@ -1993,6 +1993,18 @@ cover:
 
 debug:
 
+tca9548a:
+  - address: 0x70
+    id: multiplex0
+    scan: True
+  - address: 0x71
+    id: multiplex1
+    scan: True
+    multiplexer:
+      id: multiplex0
+      channel: 0
+    
+
 pcf8574:
   - id: 'pcf8574_hub'
     address: 0x21