diff --git a/esphome/core/helpers.cpp b/esphome/core/helpers.cpp
index 48ef406a81..53bb6bfd79 100644
--- a/esphome/core/helpers.cpp
+++ b/esphome/core/helpers.cpp
@@ -392,13 +392,16 @@ void hsv_to_rgb(int hue, float saturation, float value, float &red, float &green
 // System APIs
 
 #if defined(USE_ESP8266)
-IRAM_ATTR InterruptLock::InterruptLock() { xt_state_ = xt_rsil(15); }
-IRAM_ATTR InterruptLock::~InterruptLock() { xt_wsr_ps(xt_state_); }
+IRAM_ATTR InterruptLock::InterruptLock() { state_ = xt_rsil(15); }
+IRAM_ATTR InterruptLock::~InterruptLock() { xt_wsr_ps(state_); }
 #elif defined(USE_ESP32)
 // only affects the executing core
 // so should not be used as a mutex lock, only to get accurate timing
 IRAM_ATTR InterruptLock::InterruptLock() { portDISABLE_INTERRUPTS(); }
 IRAM_ATTR InterruptLock::~InterruptLock() { portENABLE_INTERRUPTS(); }
+#elif defined(USE_RP2040)
+IRAM_ATTR InterruptLock::InterruptLock() { state_ = save_and_disable_interrupts(); }
+IRAM_ATTR InterruptLock::~InterruptLock() { restore_interrupts(state_); }
 #endif
 
 uint8_t HighFrequencyLoopRequester::num_requests = 0;  // NOLINT(cppcoreguidelines-avoid-non-const-global-variables)
diff --git a/esphome/core/helpers.h b/esphome/core/helpers.h
index 1459f0ef55..6f3b5805cf 100644
--- a/esphome/core/helpers.h
+++ b/esphome/core/helpers.h
@@ -542,8 +542,8 @@ class InterruptLock {
   ~InterruptLock();
 
  protected:
-#ifdef USE_ESP8266
-  uint32_t xt_state_;
+#if defined(USE_ESP8266) || defined(USE_RP2040)
+  uint32_t state_;
 #endif
 };