diff --git a/nongnu/packages/steam-client.scm b/nongnu/packages/steam-client.scm
index 18543ec..b25a751 100644
--- a/nongnu/packages/steam-client.scm
+++ b/nongnu/packages/steam-client.scm
@@ -46,6 +46,7 @@
   #:use-module (gnu packages python-xyz)
   #:use-module (gnu packages toolkits)
   #:use-module (gnu packages video)
+  #:use-module (gnu packages xorg)
   #:use-module (nonguix multiarch-container)
   #:use-module (nonguix utils))
 
@@ -104,6 +105,28 @@
     (description "Steam is a digital software distribution platform created by Valve.")
     (license (license:nonfree "file:///share/doc/steam/steam_subscriber_agreement.txt"))))
 
+;; After guix commit to add a replacement for libx11 (security fixes),
+;; 5ff0c8997a2ddf71af477883584a5f9ccd9b757f, a profile collision happens with
+;; the propagated libx11 (now grafted) from mesa and its propagated-input
+;; libxdamage.  See previous upstream report (when this occurred for expat and
+;; fontconfig) at <https://issues.guix.gnu.org/53406>.  So we define explicit
+;; replacement packages to workaround this issue.
+;; TODO: remove once upstream bug is fixed or libx11 is ungrafted.
+(define libxdamage-fixed
+  (package
+    (inherit libxdamage)
+    (propagated-inputs
+     (modify-inputs (package-propagated-inputs libxdamage)
+       (replace "libx11" libx11-fixed)))))
+
+(define mesa-fixed
+  (package
+    (inherit mesa)
+    (propagated-inputs
+     (modify-inputs (package-propagated-inputs mesa)
+       (replace "libx11" libx11-fixed)
+       (replace "libxdamage" libxdamage-fixed)))))
+
 (define steam-client-libs
   `(("bash" ,bash)                      ; Required for steam startup.
     ("coreutils" ,coreutils)
@@ -126,7 +149,9 @@
     ("libvdpau-va-gl" ,libvdpau-va-gl)  ; Additional VDPAU support.
     ("llvm" ,llvm-for-mesa)             ; Required for mesa.
     ("lsof" ,lsof)                      ; Required for some friend's list actions.
-    ("mesa" ,mesa)                      ; Required for steam startup.
+    ;; TODO: Set back to mesa once libx11 is ungrafted upstream or once
+    ;; <https://issues.guix.gnu.org/53406> is fixed.
+    ("mesa" ,mesa-fixed)                ; Required for steam startup.
     ("nss-certs" ,nss-certs)            ; Required for steam login.
     ("pciutils" ,pciutils)              ; Tries to run lspci at steam startup.
     ("procps" ,procps)