diff --git a/doc/notmuch-emacs.rst b/doc/notmuch-emacs.rst
index 78528785..970cd7b7 100644
--- a/doc/notmuch-emacs.rst
+++ b/doc/notmuch-emacs.rst
@@ -493,6 +493,15 @@ Sending Mail
        :code:`compose-mail`.  To use ``notmuch`` for this, customize this
        variable to the symbol :code:`notmuch-user-agent`.
 
+:index:`message-dont-reply-to-names`
+
+       When composing mail replies, Emacs's message mode uses the
+       variable :code:`message-dont-reply-to-names` to exclude
+       recipients matching a given collection of regular expressions
+       or satisfying an arbitrary predicate.  Notmuch's MUA inherits
+       this standard mechanism and will honour your customization of
+       this variable.
+
 Init File
 ---------
 
diff --git a/emacs/notmuch-mua.el b/emacs/notmuch-mua.el
index 0ae33127..0f9ef3c2 100644
--- a/emacs/notmuch-mua.el
+++ b/emacs/notmuch-mua.el
@@ -21,7 +21,10 @@
 
 ;;; Code:
 
+(eval-when-compile (require 'subr-x))
+
 (require 'message)
+(require 'gmm-utils)
 (require 'mm-view)
 (require 'format-spec)
 
@@ -382,6 +385,21 @@ instead of `message-mode' and SWITCH-FUNCTION is mandatory."
     (erase-buffer)
     (notmuch-message-mode)))
 
+(defun notmuch-mua--remove-dont-reply-to-names ()
+  (when-let* ((nr (if (functionp message-dont-reply-to-names)
+		      message-dont-reply-to-names
+		    (gmm-regexp-concat message-dont-reply-to-names)))
+	      (nr-filter
+	       (if (functionp nr)
+		   (lambda (mail) (and (not (funcall nr mail)) mail))
+		 (lambda (mail) (and (not (string-match-p nr mail)) mail)))))
+    (dolist (header '("To" "Cc"))
+      (when-let ((v (message-fetch-field header)))
+	(let* ((tokens (mapcar #'string-trim (message-tokenize-header v)))
+	       (good-tokens (delq nil (mapcar nr-filter tokens)))
+	       (addr (and good-tokens (mapconcat #'identity good-tokens ", "))))
+	  (message-replace-header header addr))))))
+
 (defun notmuch-mua-mail (&optional to subject other-headers _continue
 				   switch-function yank-action send-actions
 				   return-action &rest ignored)
@@ -422,6 +440,7 @@ moved to the \"To:\" header."
 	(message-this-is-mail t))
     (message-setup-1 headers yank-action send-actions return-action))
   (notmuch-fcc-header-setup)
+  (notmuch-mua--remove-dont-reply-to-names)
   (message-sort-headers)
   (message-hide-headers)
   (set-buffer-modified-p nil)
diff --git a/test/T454-emacs-dont-reply-names.sh b/test/T454-emacs-dont-reply-names.sh
new file mode 100755
index 00000000..3a770177
--- /dev/null
+++ b/test/T454-emacs-dont-reply-names.sh
@@ -0,0 +1,76 @@
+#!/usr/bin/env bash
+
+test_description="message-dont-reply-to-names in emacs replies"
+. $(dirname "$0")/test-lib.sh || exit 1
+. $NOTMUCH_SRCDIR/test/test-lib-emacs.sh || exit 1
+
+EXPECTED=$NOTMUCH_SRCDIR/test/emacs-show.expected-output
+
+test_require_emacs
+
+add_email_corpus default
+
+test_begin_subtest "regular expression"
+test_emacs '(let ((message-dont-reply-to-names "notmuchmail\\|noreply\\|harvard"))
+	      (notmuch-mua-new-reply
+	        "id:20091117203301.GV3165@dottiness.seas.harvard.edu" nil t)
+	      (test-visible-output "OUTPUT-FULL.raw"))'
+
+notmuch_dir_sanitize < OUTPUT-FULL.raw > OUTPUT-FULL
+head -6 OUTPUT-FULL > OUTPUT
+
+cat <<EOF > EXPECTED
+From: Notmuch Test Suite <test_suite@notmuchmail.org>
+To: Mikhail Gusarov <dottedmag@dottedmag.net>
+Subject: Re: [notmuch] Working with Maildir storage?
+In-Reply-To: <20091117203301.GV3165@dottiness.seas.harvard.edu>
+Fcc: MAIL_DIR/sent
+--text follows this line--
+EOF
+
+test_expect_equal_file EXPECTED OUTPUT
+
+test_begin_subtest "predicate"
+test_emacs '(let ((message-dont-reply-to-names
+	           (lambda (m) (string-prefix-p "Mikhail" m))))
+	      (notmuch-mua-new-reply
+	        "id:20091117203301.GV3165@dottiness.seas.harvard.edu" nil t)
+	      (test-visible-output "OUTPUT-FULL-PRED.raw"))'
+
+notmuch_dir_sanitize < OUTPUT-FULL-PRED.raw > OUTPUT-FULL-PRED
+head -7 OUTPUT-FULL-PRED > OUTPUT-PRED
+
+cat <<EOF > EXPECTED-PRED
+From: Notmuch Test Suite <test_suite@notmuchmail.org>
+To: Lars Kellogg-Stedman <lars@seas.harvard.edu>
+Cc: notmuch@notmuchmail.org
+Subject: Re: [notmuch] Working with Maildir storage?
+In-Reply-To: <20091117203301.GV3165@dottiness.seas.harvard.edu>
+Fcc: MAIL_DIR/sent
+--text follows this line--
+EOF
+
+test_expect_equal_file EXPECTED-PRED OUTPUT-PRED
+
+test_begin_subtest "nil value"
+test_emacs '(let ((message-dont-reply-to-names nil))
+	      (notmuch-mua-new-reply
+	        "id:20091117203301.GV3165@dottiness.seas.harvard.edu" nil t)
+	      (test-visible-output "OUTPUT-FULL-NIL.raw"))'
+
+notmuch_dir_sanitize < OUTPUT-FULL-NIL.raw > OUTPUT-FULL-NIL
+head -7 OUTPUT-FULL-NIL > OUTPUT-NIL
+
+cat <<EOF > EXPECTED-NIL
+From: Notmuch Test Suite <test_suite@notmuchmail.org>
+To: Lars Kellogg-Stedman <lars@seas.harvard.edu>, Mikhail Gusarov <dottedmag@dottedmag.net>
+Cc: notmuch@notmuchmail.org
+Subject: Re: [notmuch] Working with Maildir storage?
+In-Reply-To: <20091117203301.GV3165@dottiness.seas.harvard.edu>
+Fcc: MAIL_DIR/sent
+--text follows this line--
+EOF
+
+test_expect_equal_file EXPECTED-NIL OUTPUT-NIL
+
+test_done